Article

CAPTAIN: A multimodal foundation model pretrained on co-assayed single-cell RNA and protein

2025-07-08

Abstract excerpt

Proteins act as the terminal effectors of cellular function, encoding the phenotypic consequences of genomic and transcriptomic programs. Although transcriptomic profiles serve as accessible proxies, they remain incomplete surrogates for the proteomic landscape that ultimately defines cellular phenotypes. Current single-cell foundation models, however, are trained exclusively on transcriptomes, resulting in biased...

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Literature Corpus work: 55b36670-0095-5eb4-a350-3c0996d476e4
DOI: 10.1101/2025.07.07.663366

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