Article

Investigating the Reversal of Blood-Brain Barrier Dysfunction in Human Subjects in a Neuroethical Context

2023-10-11

Abstract excerpt

<p>Dysfunction in the blood-brain barrier (BBB), a crucial component of the neurovascular unit (NVU) that regulates intercellular transport between the blood and the brain while protecting the central nervous system (CNS) from toxins and pathogens, has been identified as a potential biomarker in diagnosing a variety of neurodegenerative diseases, such as traumatic brain injuries, Alzheimer's disease, stroke, epile...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f08f2a90-7da0-5126-9415-0551cb3a2906
DOI: 10.31234/osf.io/gxepr

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the Reversal of Blood-Brain Barrier Dysfunction in Human Subjects in a Neuroethical ContextDOI 10.31234/osf.io/gxeprRead

Disrupted blood-brain barrier in 5×FAD mouse model of Alzheimer’s disease can be mimicked and repaired in vitro with neural stem cell-derived exosomesSemantic proximity Read

Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative diseaseSemantic proximity Read

The “Frail” Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell to Cell ConnectionsSemantic proximity Read

Intravenous lipid-siRNA conjugate mediates gene silencing at the blood-brain barrier and blood-CSF barrierSemantic proximity Read

Core protocol development for phase 2/3 clinical trials in the leukodystrophy Vanishing White MatterSemantic proximity Read

Blood-brain barrier dysfunction in aging induces hyper-activation of TGF-beta signaling and chronic yet reversible neural dysfunctionSemantic proximity Read

The Blood-Brain Barrier, an Evolving Concept Based on Technological Advances and Cell-Cell Communications.Semantic proximity Read

Protecting research subject welfare in preventive trials for autosomal dominant Alzheimer's disease.Semantic proximity Read

Blood-brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery.Semantic proximity Read

Therapeutic Modulation of Meningeal Lymphatics: A Systematic Review of Preclinical Evidence Across Neurological DisordersSemantic proximity Read

Foetal Allogeneic Intracerebroventricular Neural Stem Cell Transplantation in People with Secondary Progressive Multiple Sclerosis: A phase I dose-escalation clinical trialSemantic proximity Read

Evaluating the First-in-Human Clinical Trial of a Human Embryonic Stem Cell-Based TherapySemantic proximity Read