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Creation and characterisation of 11β hydroxysteroid dehydrogenase type 1 transgenic mesenchymal stem cells for use in models of acute respiratory distress syndrome

2019-09-25

Abstract excerpt

<title>Abstract</title> <p>Background: Human bone marrow mesenchymal stem cell (MSC) administration reduces inflammation in pre-clinical models of lung injury, however clinical efficacy in patients with acute respiratory distress syndrome (ARDS) has not been shown. Upregulation of the glucocorticoid activating enzyme, 11β hydroxysteroid dehydrogenase type 1 (HSD-1) within the alveolar space elevates local anti-in...

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Literature Corpus work
f05688e5-1385-5716-bee0-54dde12de7ab
DOI
10.21203/rs.2.14766/v1
Open publication

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