Article

FlashDeconv reveals resolution horizons in atlas-scale spatial transcriptomics

2025-12-25

Abstract excerpt

Coarsening Visium HD resolution from 8 to 64 µ m can flip cell-type co-localization from negative to positive ( r = −0.12 → +0.80 ), yet many widely used compositional deconvolution workflows require coarsening or subsampling at million-bin scale. Here we introduce FlashDeconv, which combines leverage-score importance sampling with sparse spatial regularization to achieve competitive benchmark accuracy while pr...

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Literature Corpus work: f020287c-3091-58f9-b447-db3ce3a887c6
DOI: 10.64898/2025.12.22.696108

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