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Article

Collagen IVα345 dysfunction in glomerular basement membrane diseases. II. Crystal structure of the α345 hexamer.

The Journal of biological chemistry - 1 Jan 2000

Boudko Sergei P, Bauer Ryan, Chetyrkin Sergei V, Ivanov Sergey, Smith Jarrod, Voziyan Paul A, Hudson Billy G

Abstract excerpt

Our recent work identified a genetic variant of the α345 hexamer of the collagen IV scaffold that is present in patients with glomerular basement membrane diseases, Goodpasture's disease (GP) and Alport syndrome (AS), and phenocopies of AS in knock-in mice. To understand the context of this "Zurich" variant, an 8-amino acid appendage, we developed a construct of the WT α345 hexamer using the single-chain NC1...

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Share to Collagen Type IV
Share to Crystallography, X-Ray

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nephritis, Hereditary

Share to Protein Multimerization

Share to Protein Structure, Quaternary

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Identifiers

PMID: 33775698
DOI: 10.1016/j.jbc.2021.100591
PMCID: PMC8093946

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