Downregulation of Cardiotrophin-Like Cytokine 1(CLCF1) Inhibits Osteoblastic Differentiation by Regulating RANKL/ OPG Pathway

Abstract excerpt

<title>Abstract</title> <p>BackgroundCardiotrophin-like cytokine factor 1 (CLCF1) is a member of the IL (interleukin)-6-type cytokine. Although its immunomodulatory functions are well defined, data on the physiological and pathological functions of the CLCF1 in bone metabolism remains scant. Here, we interrogated the functions and mechanisms of CLCF1 in osteoblast differentiation.MethodsA total of 109 patients wi...

Topics

Open a Topic to create a Post that cites this publication.

• Bone Metabolism and Diseases
• Cardiac Fibrosis and Remodeling
• Cytokine Signaling Pathways and Interactions
• DNA-Binding Proteins
• Mice
• Mice, Knockout
• Phenotype
• Signaling Pathways in Disease

Identifiers and source

Literature Corpus work

efb656f6-b01b-55a3-bf13-489bad52d70f

DOI

10.21203/rs.3.rs-111138/v1