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Powassan Viruses Spread Cell to Cell During Direct Isolation from <i>Ixodes</i> Ticks and Persistently Infect Human Brain Endothelial Cells and Pericytes

2021-10-02

Abstract excerpt

Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the Northeastern U.S., with a 2% prevalence in Long Island (LI) deer ticks ( Ixodes scapularis ). POWVs are transmitted in as little as 15 minutes of a tick bite, and enter the CNS to cause encephalitis (10% fatal) and long-term neuronal damage. POWV-LI9 and POWV-LI41 present in LI Ixodes ticks were isolated by directly inoculating Ve...

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Literature Corpus work
ef6c5b18-bacc-51d9-8abc-921f74ee0686
DOI
10.1101/2021.09.30.462684
Open publication

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Powassan Viruses Spread Cell to Cell During Direct Isolation from <i>Ixodes</i> Ticks and Persistently Infect Human Brain Endothelial Cells and PericytesDOI 10.1101/2021.09.30.462684
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