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Powassan Virus Neuropathology and Genomic Diversity in Patients With Fatal Encephalitis

29 Aug 2020

Abstract excerpt

BACKGROUND: Powassan virus (POWV) is an emerging cause of severe encephalitis; very little is known about human pathogenicity due to challenges in diagnosis and viral RNA recovery. We present 3 patients with fatal encephalitis due to POWV lineage II (deer tick virus). METHODS: We obtained 27 unique samples, including from brain biopsy and autopsy, and used metagenomic sequencing, quantitative reverse...

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PMID: 33094116
DOI: 10.1093/ofid/ofaa392

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