Back to search

Article

FMT Restores Colonic Protein Biosynthesis and Cell Proliferation in Patients with Recurrent<i>Clostridioides difficile</i>Disease

2024-12-01

Abstract excerpt

Recurrent C. difficile infection (CDI) is a major health threat with significant mortality and financial costs. Fecal Microbiota Transplantation (FMT) is an effective therapy, however the mechanisms by which it acts, particularly on the host, are poorly understood. Here we enrolled a prospective cohort of human patients with recurrent CDI (n=16) undergoing FMT therapy. Colonic biopsies were collected and bulk RNA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
eeea6f3e-5f6b-5b49-83e8-ead6937dc6d7
DOI
10.1101/2024.11.28.24318101
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
FMT Restores Colonic Protein Biosynthesis and Cell Proliferation in Patients with Recurrent<i>Clostridioides difficile</i>DiseaseDOI 10.1101/2024.11.28.24318101
Fecal microbiota transplantation increases colonic IL-25 and dampens tissue inflammation in patients with recurrent<i>Clostridioides difficile</i>Semantic proximity
Metagenomic, metabolomic, and lipidomic shifts associated with fecal microbiota transplantation for recurrent <i>Clostridioides difficile</i> infectionSemantic proximity
Pro-restitutive <i>Bacteroides thetaiotaomicron</i> reprograms the transcriptome of intestinal epithelial cells by modulating the expression of genes essential for proliferation and migrationSemantic proximity
Inter-individual Recovery of the Microbiota and Metabolome Over Time Following Fecal Microbiota Transplantation in Patients with Recurrent <i>Clostridium difficile</i> InfectionSemantic proximity
Analysis of the Intestinal Microbiome of a Recovered Clostridium difficile Patient after Fecal TransplantationSemantic proximity
Integrated metagenomic and bile acid metabolomic analysis of human fecal microbiota transplantation for recurrent Clostridioides difficile and/or inflammatory bowel diseasesSemantic proximity
Upfront fecal microbiota transplantation for the management of immune checkpoint inhibitor mediated diarrhea and colitisSemantic proximity
Host origin of microbiota drives functional recovery and <i>Clostridioides difficile</i> clearance in miceSemantic proximity
A New Hypothesis for <em>Clostridioides difficile</em> Infection Vulnerability: Epithelial Damage and Inflammatory Repair May Prime the Host for InfectionSemantic proximity
Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent <i>Clostridium difficile</i> infectionSemantic proximity
Dual RNA-seq identifies proteins and pathways modulated during <i>Clostridioides difficile</i> colonisationSemantic proximity
A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile InfectionSemantic proximity
Select a neighboring publication to make it the new centre.