Article

Potent Neutralizing Activity of Polyclonal Equine Antibodies against Omicron SARS-CoV-2

2022-02-23

Abstract excerpt

Using a polyclonal approach of equine anti-SARS-CoV-2 F(ab’)2 antibodies we have achieved a high level of neutralizing potency against all SARS-CoV-2 variants tested. Neutralization titers were in the range of 10 5 -10 6 IU/mL including Omicron: 111,403 UI/mL, which is 2-3 orders of magnitude what is normally achieved in response to SARS-CoV-2 infection and/or vaccination. The presence of high titers of a repert...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee34b7cb-e704-5812-a5da-410ee9f87455
DOI: 10.1101/2022.02.21.481341

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Potent Neutralizing Activity of Polyclonal Equine Antibodies against Omicron SARS-CoV-2DOI 10.1101/2022.02.21.481341Read

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 VariantsSemantic proximity Read

Development of equine antisera with high neutralizing activity against SARS-CoV-2Semantic proximity Read

Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheepSemantic proximity Read

Deletion of the ORF2 gene of the neuropathogenic equine herpesvirus type 1 strain Ab4 reduces virulence while maintaining strong immunogenicitySemantic proximity Read

Potent monoclonal antibody–mediated neutralization of a divergent Hendra virus variantSemantic proximity Read

Neutralization determinants of laboratory strains and field isolates of equine arteritis virus: identification of four neutralization sites in the amino-terminal ectodomain of the G(L) envelope glycoprotein.Semantic proximity Read

Cross-neutralization and antigenic characterization of simian and equine group A rotaviruses.Semantic proximity Read

Monoclonal antibodies directed against conserved epitopes on the nucleocapsid protein and the major envelope glycoprotein of equine arteritis virus.Semantic proximity Read