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Article

Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza

2020-02-21

Abstract excerpt

<h4>Background: </h4> Host-derived inflammatory responses contribute to the morbidity and mortality of severe influenza, suggesting that immunomodulatory therapy may improve outcomes. The normally circulating protein, human plasma gelsolin, is available in recombinant form (rhu-pGSN) and has beneficial effects in a variety of pre-clinical models of inflammation and injury.   <h4>Methods: </h4>: We evaluated delay...

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Literature Corpus work
ee164e03-dd4e-5e7e-ae8a-d28dd5610e96
DOI
10.12688/f1000research.21082.2
Open publication

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