Article

Ancestry adjustment improves genome-wide estimates of regional intolerance

2020-03-06

Abstract excerpt

Genomic regions subject to purifying selection are more likely to carry disease causing mutations. Cross species conservation is often used to identify such regions but has limited resolution to detect selection on short evolutionary timescales such as that occurring in only one species. In contrast, intolerance looks for depletion of variation relative to expectation within a species, allowing species specific fe...

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Literature Corpus work: ed7df95f-b444-5d49-9f93-9724acc7e3c0
DOI: 10.1101/2020.03.05.979203

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