Article

Diverse ancestral representation improves genetic intolerance metrics

2024-11-06

Abstract excerpt

<h4>Summary</h4> Rapidly expanding genomic databases have enabled the identification of regions in the human genome intolerant to variation and thus likely relevant to human disease. However, despite their unprecedented scale, these datasets remain constrained by limited ancestral diversity. Here, we systematically evaluate how genetic diversity impacts gene- and sub-genic intolerance metrics by analyzing whole-e...

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Literature Corpus work: 1af7a9b3-1f18-56a3-95c9-7201ed5afbe1
DOI: 10.1101/2024.11.04.621955

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