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OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target Discovery

2025-06-06

Abstract excerpt

Here, we present OriGene, a self-evolving multi-agent system that functions as a virtual disease biologist, systematically identifying original and mechanistically grounded therapeutic targets at scale. OriGene’s architecture integrates over 600 specialized tools through a Model Context Protocol (MCP), enabling it to reason across diverse data modalities including genomics, protein networks, pharmacology, clinical...

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Identifiers and source

Literature Corpus work
06df0091-8406-53e2-992d-a79bbe22f85f
DOI
10.1101/2025.06.03.657658
Open publication

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OriGene: A Self-Evolving Virtual Disease Biologist Automating Therapeutic Target DiscoveryDOI 10.1101/2025.06.03.657658
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