Article

Cystinosin/Ers1 functions in redox homeostasis in the early secretory pathway

2026-03-02

Abstract excerpt

Cystinosis is an autosomal recessive inherited disorder caused by mutations in the CTNS gene, which encodes the highly conserved transmembrane protein cystinosin, a proton/cystine co-transporter at the lysosome membrane. However, reduction of cystine load in the lysosomes is insufficient to treat key disease symptoms, indicating that cystinosin performs additional disease-relevant functions. Here, we report that...

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Literature Corpus work: ec84c936-5f49-5213-9cef-1f10c77ea65d
DOI: 10.64898/2026.03.01.708828

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