Article

The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an <i>in vitro</i> ALS Model

2020-07-26

Abstract excerpt

Aggregation of Cu-Zn superoxide dismutase (SOD1) is implicated in the motor neuron disease, ALS. Although more than 140 disease mutations of SOD1 are available, their stability or aggregation behaviors in membrane environment are not correlated with disease pathophysiology. Here, we use multiple mutational variants of SOD1 to show that the absence of Zn, and not Cu, significantly impacts membrane attachment of SOD...

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Literature Corpus work: ec683259-23bd-5965-bad2-a5786bb4b86a
DOI: 10.1101/2020.07.25.220962

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