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Article

Study of mutation and misfolding of Cu-Zn SOD1 protein.

Journal of biomolecular structure & dynamics - 1 Jan 2015

Keerthana S P, Kolandaivel P

Abstract excerpt

The main objective of this work is to determine the mechanism for misfolding and aggregation as a result of mutations in Cu-Zn superoxide dismutase1. The quantum mechanical approach is beneficial for investigating the early stages of mutation, misfolding, and loss of protection of the native structures involved in the neuro-degeneration disease Amyotrophic Lateral Sclerosis. All the structures were optimized...

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Source

Identifiers

PMID: 24320678
DOI: 10.1080/07391102.2013.865104

Genes

MIA
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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