Article

Plerixafor Engages β-Arrestin–Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin–MITF Activation

2026-06-02

Abstract excerpt

Plerixafor is a clinically approved CXCR4 antagonist that mobilizes hematopoietic stem cells by disrupting CXCL12/CXCR4 retention signaling. However, its biochemical effects on melanocytes and pigmentation remain unexplored. We investigated how plerixafor modulates CXCR4 sig-naling in melanocytes and evaluated its potential as a pro-melanogenic agent using in vitro and in vivo approaches. Human PIG1 melanocytes we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ebb21f3e-a5cf-529e-aa8d-e1d9b51a420c
DOI: 10.20944/preprints202603.1777.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Plerixafor Engages β-Arrestin–Dependent CXCR4 Signaling to Promote Melanogenesis via β-Catenin–MITF ActivationDOI 10.20944/preprints202603.1777.v2Read

Plerixafor Biases CXCR4 Signaling Through β-Arrestin to Promote Melanogenesis via β-Catenin–MITF ActivationSemantic proximity Read

Trends in Regenerative Medicine: Repigmentation in Vitiligo Through Melanocyte Stem Cell MobilizationSemantic proximity Read

Anti‐melanogenic effect of exosomes derived from human dermal fibroblasts (BJ‐5ta‐Ex) in C57BL/6 mice and B16F10 melanoma cellsSemantic proximity Read

New Mechanistic Insights of MelasmaSemantic proximity Read

Cajanin Suppresses Melanin Synthesis through Modulating MITF in Human Melanin-Producing CellsSemantic proximity Read

JNK suppresses melanogenesis by interfering with CREB-regulated transcription coactivator 3-dependent MITF expressionSemantic proximity Read

A high-throughput screening platform for pigment regulating agents using pluripotent stem cell derived melanocytesSemantic proximity Read

Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanomaSemantic proximity Read

Metformin inhibits melanin synthesis and melanosome transfer through the cAMP pathwaySemantic proximity Read

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human SkinSemantic proximity Read

CD34 defines melanocyte stem cell subpopulations with distinct regenerative propertiesSemantic proximity Read

Selaginellin Inhibits Melanogenesis via the MAPK Signaling PathwaySemantic proximity Read