Article

Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetes

2024-11-18

Abstract excerpt

Management of labor in women with diabetes is challenging due to the high risk of peri- and postpartum complications. To avoid cesarean section and assist with labor progression, Pitocin, a synthetic oxytocin, is frequently used to induce and augment labor. However, the efficacy of Pitocin is often compromised in diabetic pregnancies, leading to increased cesarian delivery. As diabetes deregulates the body’s circa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaf1ef55-ed5a-5580-ab43-3c0ae691575f
DOI: 10.1101/2024.11.16.622460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interaction between time-of-day and oxytocin efficacy in mice and humans with and without gestational diabetesDOI 10.1101/2024.11.16.622460Read

Oxytocin in the circadian timing of birth.Semantic proximity Read

Generation of myometrium-specific Bmal1 knockout mice for parturition analysisSemantic proximity Read

Parturition dysfunction in obesity: time to target the pathobiology.Semantic proximity Read

The Circadian Clock, Nutritional Signals and Reproduction: A Close RelationshipSemantic proximity Read

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and DiseaseSemantic proximity Read

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.Semantic proximity Read

Circadian System and Melatonin Hormone: Risk Factors for Complications during PregnancySemantic proximity Read

Clock gene expression in gravid uterus and extra-embryonic tissues during late gestation in the mouseSemantic proximity Read

Disruption of the Expression of the Placental Clock and Melatonin Genes in PreeclampsiaSemantic proximity Read

Oxytocin induces embryonic diapauseSemantic proximity Read

Induction of Core Circadian Clock Transcription Factor Bmal1 Enhances β-Cell Function and Protects Against Obesity-Induced Glucose IntoleranceSemantic proximity Read

Laplace’s Law and Pascal’s Principle Dictate Birth Timing and Pregnancy Duration Through Exponential Uterine Wall Tension (EUWT) Where Its Malfunctions Alter Birth Timing and/or Mode of Delivery: A HypothesisSemantic proximity Read