Article

Activation of FAM111A Protease Induces Defects in Nuclear Function that Likely Underlie its Roles in Disease and Viral Restriction

2020-05-05

Abstract excerpt

Mutations in the nuclear trypsin-like serine protease FAM111A cause Kenny-Caffey syndrome (KCS2) with hypoparathyroidism and skeletal dysplasia, or perinatally lethal osteocraniostenosis (OCS). In addition, FAM111A was identified as a restriction factor for certain host range mutants of the SV40 polyomavirus and VACV orthopoxvirus. However, because FAM111A function is poorly characterized, its roles in restricting...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea4882fb-230d-5ecd-a65d-0152a4cb9c37
DOI: 10.1101/2020.05.04.077594

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Activation of FAM111A Protease Induces Defects in Nuclear Function that Likely Underlie its Roles in Disease and Viral RestrictionDOI 10.1101/2020.05.04.077594Read

Gain-of-function mutations amplify cytotoxic FAM111 protease activity in human genetic disordersSemantic proximity Read

Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications.Semantic proximity Read

FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease.Semantic proximity Read

Loss of FAM111B protease mutated in hereditary fibrosing poikiloderma syndrome negatively regulates telomere lengthSemantic proximity Read

Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range PhenotypeSemantic proximity Read

Functions and evolution of FAM111 serine proteasesSemantic proximity Read

Human FAM111A inhibits vaccinia virus replication by degrading viral DNA-binding protein I3 and is antagonized by poxvirus host range factor SPI-1Semantic proximity Read

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1Semantic proximity Read

FAM111A regulates replication origin activation and cell fitnessSemantic proximity Read

E2F3-dependent activation of FAM111B restricts mouse cytomegalovirus replication in primate cellsSemantic proximity Read

Proposed Cellular Function of the Human FAM111B Protein and Dysregulation in Fibrosis and CancerSemantic proximity Read

A novel FAM111A frameshift variant associated with osteoclast necroptosis and KCS2-like syndromeSemantic proximity Read