Article

Transcriptional plasticity of stromal cells amplifies their differentiation efficiency <i>in vitro</i>

2025-04-21

Abstract excerpt

Human bone marrow-derived stromal cells (also termed mesenchymal stem cell -MSCs) are progenitors capable of differentiating into bone forming osteoblasts and fat storing adipocytes. Due to the loss of bone mass being associated with increased marrow fat, trans-differentiation of osteoblasts into adipocytes been hypothesized as a contributor to osteoporotic bone loss and fragility. Reprogramming of transcriptional...

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Literature Corpus work: e98b6c69-afea-513b-8a3e-1e5793cb61d3
DOI: 10.1101/2025.04.18.649582

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