Article
Osteogenic imprinting upstream of marrow stromal cell differentiation.
Journal of cellular biochemistry - 6 Jun 2000
Satomura K, Krebsbach P, Bianco P, Gehron Robey P
Abstract excerpt
Five spontaneously transformed cell lines were established from a population of murine bone marrow stromal cells (BMSCs) and the expression profiles of phenotype-characteristic genes, patterns of in vitro differentiation, and osteogenic capacity after in vivo transplantation were determined for each. All the clones expressed stable levels of cbfa1, the osteogenic "master" gene, whereas the levels of individual...
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