Back to search

Article

PPP-COMPUTE: A Pandemic Pharmacology Platform for COMPUTational Evaluation of Anti-infectives in Pandemic Preparedness

2026-08-02

Abstract excerpt

A global pandemic requires accelerated strategies to mitigate public healthcare risks and preserve societal stability, either by repurposing existing drugs or by rapidly developing novel drug candidates. Computational platforms have accelerated candidate identification for both routes. A critical gap is the translation from in vitro potency to predicted clinical efficacy, which determines whether a prioritized ca...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e9514458-9a24-5d1e-866f-19f6c6fbd4c1
DOI
10.64898/2026.07.30.26359333
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PPP-COMPUTE: A Pandemic Pharmacology Platform for COMPUTational Evaluation of Anti-infectives in Pandemic PreparednessDOI 10.64898/2026.07.30.26359333
A Quantitative Systems Pharmacology Model of the Pathophysiology and Treatment of COVID-19 Predicts Optimal Timing of Pharmacological InterventionsSemantic proximity
Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19Semantic proximity
Design and implementation of an international, multi-arm, multi-stage platform master protocol for trials of novel SARS-CoV-2 antiviral agents: Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3)Semantic proximity
The IDentif.AI 2.0 Pandemic Readiness Platform: Rapid Prioritization of Optimized COVID-19 Combination Therapy RegimensSemantic proximity
Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory responseSemantic proximity
Developing New Drugs for the COVID-19 Emergency: Anatomy of the U.S. Response.Semantic proximity
Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to HumansSemantic proximity
Numerical approaches for the rapid analysis of prophylactic efficacy against HIV with arbitrary drug-dosing schemesSemantic proximity
Required concentration index quantifies effective drug combinations against hepatitis C virus infectionSemantic proximity
Pharmacometric assessment of the <i>in vivo</i> antiviral activity of ivermectin in early symptomatic COVID-19Semantic proximity
Required concentration index quantifies effective drug combinations against hepatitis C virus infection.Semantic proximity
Integrating Patient Metadata and Genetic Pathogen Data: Advancing Pandemic Preparedness with a Multi-Parametric SimulatorSemantic proximity
Select a neighboring publication to make it the new centre.