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The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production is correlated with decreased virulence in diverse clinical isolates in osteomyelitis

2022-11-08

Abstract excerpt

We previously demonstrated that MgrA, SarA, SarR, SarS, SarZ, and Rot bind at least three of the four promoters associated with genes encoding primary extracellular proteases in Staphylococcus aureus . We also showed that mutation of sarA results in a greater increase in protease production, and decrease in biofilm formation, than mutation of the loci encoding any of these other proteins. However, these conclusi...

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Literature Corpus work
e921d454-d9fe-52e9-b5de-e10effc59ede
DOI
10.1101/2022.11.07.515558
Open publication

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The major role of <i>sarA</i> in limiting <i>Staphylococcus aureus</i> extracellular protease production is correlated with decreased virulence in diverse clinical isolates in osteomyelitisDOI 10.1101/2022.11.07.515558
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