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Efficacy and Mechanism of the Combination of PARP and CDK4/6 Inhibitors in the Treatment of Triple-negative Breast Cancer

2020-12-14

Abstract excerpt

<h4>Background: </h4> PARP inhibitors (PARPi) benefit only a fraction of breast cancer patients with BRCA mutations and their efficacy is even more limited in triple-negative breast cancer (TNBC) due to clinical primary and acquired resistance. Here, we found that the efficacy of PARPi in TNBC can be improved with CDK4/6 inhibitors (CDK4/6i). <h4>Methods: </h4>: We screened primary PARPi-sensitive and resistant ce...

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Literature Corpus work
e85a13ec-8492-50d2-ada9-ea283a1b5b36
DOI
10.21203/rs.3.rs-125331/v1
Open publication

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Efficacy and Mechanism of the Combination of PARP&nbsp;and CDK4/6 Inhibitors in the Treatment of Triple-negative Breast CancerDOI 10.21203/rs.3.rs-125331/v1
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