Article

Progression of a Muscular Dystrophy Due to a Genetic Defect in Membrane Synthesis is Driven by Large Changes in Neutral Lipid Metabolism

2021-05-19

Abstract excerpt

<title>Abstract</title> <p>CHKB encodes one of two mammalian choline kinase enzymes that catalyze the first step in the synthesis of the major membrane phospholipid, phosphatidylcholine (PC). In humans, inactivation of the CHKB gene causes a recessive form of a rostral-to-caudal congenital muscular dystrophy. Using Chkb knockout mice, we reveal that at no stage of the disease is PC level significantly altered. In...

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Literature Corpus work: e8218846-df70-55ce-921b-4f3f4bf04425
DOI: 10.21203/rs.3.rs-64129/v1

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