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Greater lean-body-mass decline with tirzepatide than semaglutide in routine care, revealed by body-composition digital phenotyping

2026-04-13

Abstract excerpt

GLP-1 receptor agonists induce substantial weight loss, but the extent to which lean tissue and physical function are preserved in routine care remains poorly understood. Using an EHR-linked body-composition digital phenotyping pipeline with LLM-based extraction, we performed a large-scale longitudinal analysis of 670,422 first-episode GLP-1RA users, including 456,742 treated with semaglutide and 213,680 treated w...

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Literature Corpus work
e81d04ae-1ba7-555d-9c92-63567fd48c33
DOI
10.64898/2026.04.11.26350687
Open publication

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Greater lean-body-mass decline with tirzepatide than semaglutide in routine care, revealed by body-composition digital phenotypingDOI 10.64898/2026.04.11.26350687
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