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Endogenous Incretin Secretagogue Compositions as a Mechanistic Class Versus Pharmacological Incretin Receptor Agonists for Weight Reduction in Overweight Adults: A Real-World Observational Cohort Analysis of a Nutraceutical Composition (Trimsulin) and Comparison with Published Outcomes for Semaglutide and Tirzepatide

2026-05-12

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<title>Abstract</title> <p> <bold>Background:</bold> Pharmacological glucagon-like peptide-1 receptor agonists (GLP-1RAs) such as semaglutide and dual glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonists such as tirzepatide produce clinically meaningful weight reduction in adults with overweight or obesity. However, gastrointestinal and serious adverse events affect a substantial proportio...

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Literature Corpus work
b2b7a9ec-4e9a-56e5-ba1e-10ccf96e4445
DOI
10.21203/rs.3.rs-9657897/v1
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Endogenous Incretin Secretagogue Compositions as a Mechanistic Class Versus Pharmacological Incretin Receptor Agonists for Weight Reduction in Overweight Adults: A Real-World Observational Cohort Analysis of a Nutraceutical Composition (Trimsulin) and Comparison with Published Outcomes for Semaglutide and TirzepatideDOI 10.21203/rs.3.rs-9657897/v1
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