Article

Dynamic Transcriptomic Remodeling in Human Neural Progenitor Cells Reveals Mechanisms for Vision Preservation in Retinitis Pigmentosa Model

2025-01-07

Abstract excerpt

<h4>SUMMARY</h4> Human neural progenitor cells (hNPCs) have shown promise in slowing down retinal degeneration in animal models and are currently being tested in clinical trials for treating retinitis pigmentosa (RP). However, the status of grafted hNPCs and their interaction with host retinal cells over time is largely unknown. Here, we investigated single-cell transcriptomic changes in grafted hNPCs and host re...

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Literature Corpus work: e7eb3267-5f75-5bba-b825-ec6fba8b6b6c
DOI: 10.1101/2025.01.06.631620

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