Article

Microbiota-derived butyrate promotes dermal collagen production through epidermal-dermal crosstalk

2026-06-16

Abstract excerpt

The commensal microbiota actively shapes skin homeostasis by regulating immune responses and barrier function, yet interactions with the dermis and dermal fibroblasts remain poorly defined. Here, we show that the commensal microbiota regulates dermal collagen homeostasis through epidermal-mediated signaling. Transcriptomic analysis revealed enrichment of extracellular matrix (ECM)-associated gene programs in the d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e7c9e385-5ab0-5db3-a19b-26048a98153b
DOI: 10.64898/2026.06.15.731906

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microbiota-derived butyrate promotes dermal collagen production through epidermal-dermal crosstalkDOI 10.64898/2026.06.15.731906Read

A mixed community of skin microbiome representatives influences cutaneous processes more than individual membersSemantic proximity Read

A Mixed Community of Skin Microbiome Representatives Influences Cutaneous Processes more than Individual MembersSemantic proximity Read

Commensal microbiota modulate gene expression in the skinSemantic proximity Read

Potential Clinical Applications of the Postbiotic Butyrate in Human Skin DiseasesSemantic proximity Read

Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healingSemantic proximity Read

Collagen diversity in human skin: Aging, wound healing, and disordersSemantic proximity Read

Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptorSemantic proximity Read

Toward the Next Generation of In Silico Modeling of Dynamic Host-Microbiota Interactions in the SkinSemantic proximity Read

Skin microbiome promotes mast cell maturation by triggering stem cell factor production in keratinocytesSemantic proximity Read

Intestinal Dysbiosis Exacerbates the Pathogenesis of Psoriasis-Like Phenotype Through Changes in Fatty Acid MetabolismSemantic proximity Read

Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomesSemantic proximity Read

Mast cell tolerance in the skin microenvironment to commensal bacteria is controlled by fibroblastsSemantic proximity Read