Article

Methods for Neuroscience Drug Development: Guidance on Standardization of the Process for Defining Clinical Outcome Strategies in Clinical Trials

2024-04-02

Abstract excerpt

<p>Neurosciences clinical trials continue to have notoriously high failure rates. Appropriate outcomes selection in early clinical trials is key to maximizing the likelihood of identifying new treatments in psychiatry and neurology. The field lacks good standards for designing outcome strategies, therefore The Outcomes Research Group was formed to develop and promote good practices in outcome selection. This artic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6e27e55-4e7a-52fe-b86a-ae7b7ae68c8f
DOI: 10.31234/osf.io/ju4ya

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Methods for Neuroscience Drug Development: Guidance on Standardization of the Process for Defining Clinical Outcome Strategies in Clinical TrialsDOI 10.31234/osf.io/ju4yaRead

Systematic Living Evidence for Clinical Trials (SyLECT): a data-driven framework for drug selection in clinical trials in motor neuron diseaseSemantic proximity Read

Development of a Core Outcome Set for Neurological Disorders (COS-Neuro): an AI-Assisted Thematic Framework AnalysisSemantic proximity Read

A Methodological Review of Randomised n-of-1 Trials.Semantic proximity Read

Guidance for defining outcomes in clinical trialsSemantic proximity Read

Seizure Prophylaxis Versus Epilepsy Prevention After Acquired Brain Injury: A Cross-Sectional ClinicalTrials.gov Registry Analysis, 2000-2026Semantic proximity Read

A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron DiseaseSemantic proximity Read

Task Force on Strategic Research Direction: Clinical Science Subgroup key science topics report.Semantic proximity Read

Exploring scalable assessment methods for terminated trials in ClinicalTrials.gov: A cohort analysis of German and Californian trialsSemantic proximity Read

The development of a set of key points to aid clinicians and researchers in designing and conducting n-of-1 trialsSemantic proximity Read

How to Evaluate Clinically Relevant Literature: Five Simple Rules for the Practicing Clinician in Stroke NeurorehabilitationSemantic proximity Read

Disease stages and therapeutic hypotheses in two decades of neurodegenerative disease clinical trialsSemantic proximity Read

The Comparability of Manual vs. Algorithm-Based Calculation of Clinical Trial Methodological Quality IndicesSemantic proximity Read