Article

Adjuvantation of whole-killed Leishmania vaccine with anti-CD200 and anti-CD300a antibodies potentiates its efficacy and provides strong protection against virulent parasites

2022-07-26

Abstract excerpt

<title>Abstract</title> The poor abilities of parasitic antigens to induce cell-mediated immunity is one of the major reasons for the limited success of vaccine candidates against all forms of leishmaniasis. Here we find, for the first time, that the adjuvantation of whole-killed Leishmania vaccine with anti-CD200 and anti-CD300a antibodies significantly enhances CD4+ T cells mediated immunity in vaccinated an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e6d7c9bc-15dd-5cc0-81b5-cf9b9be789d4
DOI: 10.21203/rs.3.rs-1817941/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Adjuvantation of whole-killed Leishmania vaccine with anti-CD200 and anti-CD300a antibodies potentiates its efficacy and provides strong protection against virulent parasitesDOI 10.21203/rs.3.rs-1817941/v1Read

Vaccine candidates, immuno-dominant antigens, and potent vaccine adjuvants for preventing cutaneous leishmaniasis: a sysSemantic proximity Read

Design of a multi-epitope subunit vaccine for immune-protection against Leishmania parasiteSemantic proximity Read

Leishmania antigens activated CD4+ T cells expressing CD200R receptors are the prime IL-10 producing phenotype and an important determinant of visceral leishmaniasis pathogenesis.Semantic proximity Read

Immunogenicity Evaluation of a Novel Lentiviral Vaccine Expressing Multi- Epitope Against of Leishmania Major in BALB/c MiceSemantic proximity Read

Protective or Detrimental? Understanding the Role of Host Immunity in LeishmaniasisSemantic proximity Read

Leishmaniavaccines: progress and problemsSemantic proximity Read

Unraveling the Immune Response Dynamics of Leishmaniasis: Insights, Challenges, and Vaccine DevelopmentSemantic proximity Read

Immune Responses in Leishmaniasis: An OverviewSemantic proximity Read

Vaccination with Heat-killed Leishmania Antigen or Recombinant Leishmanial Protein and CpG Oligodeoxynucleotides Induces Long-Term Memory CD4+and CD8+T Cell Responses and Protection Against Leishmania major InfectionSemantic proximity Read

Differences in immune responses against Leishmania induced by infection and by immunization with killed parasite antigen: implications for vaccine discoverySemantic proximity Read

Safety, immunogenicity, and efficacy of a gentamicin-attenuated Leishmania major vaccine in an open-label clinical vaccine trialSemantic proximity Read

An immunoinformatic approach driven by experimental proteomics: in silico design of a subunit candidate vaccine targeting secretory proteins of Leishmania donovani amastigotesSemantic proximity Read