Article

CRISPR-Cas9 interference in cassava linked to the evolution of editing-resistant geminiviruses

2018-05-04

Abstract excerpt

<h4>ABSTRACT</h4> We used CRISPR-Cas9 in the staple food crop cassava with the aim of engineering resistance to African cassava mosaic virus , a member of a widespread and important family of plant-pathogenic DNA viruses. We found that between 33 and 48% of edited virus genomes evolved a conserved single-nucleotide mutation that confers resistance to CRISPR-Cas9 cleavage. Our study highlights the potential for v...

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Literature Corpus work: e6bfc5a7-27f2-51b2-b565-155aacc9c26f
DOI: 10.1101/314542

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