Article

In Vitro Modulation of MECP2 Expression via Antisense Inhibition of miR-132-3p in SH-SY5Y Cells

2025-10-06

Abstract excerpt

Rett syndrome (RTT) is a severe neurodevelopmental disorder that predominantly affects females. It is characterized by developmental regression during infancy, including loss of speech, gait abnormalities, intellectual disability, seizures, respiratory issues, and stereotypic hand movements. RTT is mainly caused by spontaneous, non-inherited mutations in the methyl-CpG-binding protein 2 (MECP2) gene located on the...

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Literature Corpus work: e651cb31-a700-59c2-8434-975b3819a324
DOI: 10.1101/2025.10.06.680678

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