Article

AKAP8 regulates R-loop balance and promotes growth of lung carcinoma cell

2024-09-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> RNA:DNA hybrid structure known as R-loop, which forms during transcription plays a pivotal roles in transcriptional regulation. Dysregulation of R-loop dynamics disrupt normal DNA replication or RNA transcription, potentially leading to disturbances of cell metabolism, abnormal cell proliferation and disease progression.<bold>Methods</bold> Interactome data of nu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5f1c5f7-237b-511f-851a-45ab92865744
DOI: 10.21203/rs.3.rs-4868523/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AKAP8 regulates R-loop balance and promotes growth of lung carcinoma cellDOI 10.21203/rs.3.rs-4868523/v1Read

AKAP8 interacting with DDX5 to regulate R-loop balance involves in lung carcinoma cell growthSemantic proximity Read

Systemic Analysis of the Dna Replication Regulators Origin Recognition Complex in Lung Adenocarcinomas Identifies Prognostic and Expression SignificanceSemantic proximity Read

CircKEAP1 serves as a ceRNA to suppress lung adenocarcinoma progression by activating KEAP1 signal pathwaySemantic proximity Read

Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significanceSemantic proximity Read

H2AFX modulates lung adenocarcinoma cell progression through the PPM1G-MAPK signaling axisSemantic proximity Read

Rbm15 mediated m6A RNA modification participates in the regulation of AKAP2 on chondrogenesisSemantic proximity Read

A novel feedback loop between high MALAT-1 and low miR-200c-3p promotes cell migration and invasion in pancreatic ductal adenocarcinoma and is predictive of poor prognosisSemantic proximity Read

Comprehensive analysis of AK4 as a potential biomarker and analysis and validation of lung adenocarcinomaSemantic proximity Read

A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinomaSemantic proximity Read

Long Noncoding RNA LINC00518 Contributes to Proliferation and Metastasis in Lung Adenocarcinoma via the miR-335-3p/CTHRC1 AxisSemantic proximity Read

A novel lncRNA-hidden polypeptide regulates malignant phenotypes and pemetrexed sensitivity in A549 pulmonary adenocarcinoma cells.Semantic proximity Read

Aberrant Expression of Proteins Involved in Signal Transduction and DNA Repair Pathways in Lung Cancer and Their Association with Clinical ParametersSemantic proximity Read