Article

Molecular Mechanisms and Differences in Lynch Syndrome Developing into Colorectal Cancer and Endometrial Cancer Based on Gene Expression, Methylation and Mutation Analysis

2022-02-08

Abstract excerpt

<h4>Purpose: </h4> The aim of this study was to screen biomarkers specific to Lynch syndrome (LS) with colorectal cancer (CRC) or endometrial cancer (EC) to explore the mechanisms by which LS develops into CRC and EC and their differences. Methods Differentially expressed or differentially methylated genes and differential mutations were identified in 10 LS, 50 CRC and 50 EC patients from TCGA, and genes overlapp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e59cf415-24bd-511b-b338-30ff3ada69d9
DOI: 10.21203/rs.3.rs-320385/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Mechanisms and Differences in Lynch Syndrome Developing into Colorectal Cancer and Endometrial Cancer Based on Gene Expression, Methylation and Mutation AnalysisDOI 10.21203/rs.3.rs-320385/v1Read

Molecular mechanisms and differences in lynch syndrome developing into colorectal cancer and endometrial cancer based on gene expression, methylation, and mutation analysis.Semantic proximity Read

Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in ChinaSemantic proximity Read

Recent advances in Lynch syndromeSemantic proximity Read

Comparison of Molecular, Clinicopathological, and Pedigree Differences Between Lynch-like and Lynch SyndromesSemantic proximity Read

Lynch syndrome related endometrial cancer: clinical significance beyond the endometriumSemantic proximity Read

Distinct clinical and genetic mutation characteristics in sporadic and Lynch syndrome-associated endometrial cancer in a Chinese population.Semantic proximity Read

A brief review of Lynch syndrome: understanding the dual cancer risk between endometrial and colorectal cancerSemantic proximity Read

Lynch Syndrome-Associated Cancers Beyond Colorectal Cancer.Semantic proximity Read

Advances in the study of Lynch syndrome in China.Semantic proximity Read

Genomic Comparison of Endometrioid Endometrial Carcinoma and Its Precancerous Lesions in Chinese Patients by High-Depth Next Generation SequencingSemantic proximity Read

Lynch Syndrome-associated Genomic Variants.Semantic proximity Read

Prevalence of cancer susceptibility variants in patients with multiple Lynch syndrome related cancersSemantic proximity Read