Article

Specific immune-regulatory transcriptional signatures reveal sex and age differences in SARS-CoV-2 infected patients

2020-11-16

Abstract excerpt

<h4>ABSTRACT</h4> The coronavirus disease 2019 (COVID-19) fatality rate varies in different patient groups. However, the underlying mechanisms that explain this variation are poorly understood. Here, we reanalyzed and integrated public RNAseq datasets of nasopharyngeal swabs and peripheral blood leukocytes from patients with SARS-CoV-2, comparing transcription patterns according to sex, age, and viral load. We fou...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e55a4ae2-3649-5e16-a114-58870d55233b
DOI: 10.1101/2020.11.12.20230417

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Specific immune-regulatory transcriptional signatures reveal sex and age differences in SARS-CoV-2 infected patientsDOI 10.1101/2020.11.12.20230417Read

Multimodal single-cell omics analysis identifies epithelium–immune cell interactions and immune vulnerability associated with sex differences in COVID-19Semantic proximity Read

Transcriptomic dysregulations associated with SARS-CoV-2 infection in human nasopharyngeal and peripheral blood mononuclear cellsSemantic proximity Read

<i>In vivo</i> antiviral host response to SARS-CoV-2 by viral load, sex, and ageSemantic proximity Read

Candidate genes of SARS-CoV-2 gender susceptibility.Semantic proximity Read

Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 ImmunopathologySemantic proximity Read

Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategiesSemantic proximity Read

Characterisation of the blood RNA host response underpinning severity in COVID-19 patientsSemantic proximity Read

Dual RNA-Seq Analysis of SARS-CoV-2 Correlates Specific Human Transcriptional Response Pathways Directly to Viral ExpressionSemantic proximity Read

Dual RNA-Seq analysis of SARS-CoV-2 correlates specific human transcriptional response pathways directly to viral expressionSemantic proximity Read

Meta-analysis of virus-induced host gene expression reveals unique signatures of immune dysregulation induced by SARS-CoV-2Semantic proximity Read

Age-associated differences in mucosal and systemic host responses to SARS-CoV-2 infectionSemantic proximity Read

Integrated Transcriptomic Analysis Reveals Distinct Immune Response Signatures and Prognostic Biomarkers in SARS-CoV-2 InfectionSemantic proximity Read