Article

Altered T1w/T2w-FLAIR Ratio in White Matter Hyperintensities as an Indicator of Structural Integrity Loss: Association with Alzheimer’s Disease and Vascular Dementia

2026-07-30

Abstract excerpt

<h4>Background</h4> White matter hyperintensities (WMH) are prevalent in dementia, but lesion volume does not capture their microstructural heterogeneity. The T1-weighted to fluid-attenuated inversion recovery (T1w/T2w-FLAIR) ratio is sensitive to myelin, gliosis, and tissue water. We tested whether lesion-specific T1w/T2w-FLAIR ratio, referenced to each participant’s normal-appearing white matter (NAWM), differs...

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Literature Corpus work: e4bb482b-c120-5d51-88bc-629f7b3d5728
DOI: 10.64898/2026.07.28.26359139

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