Article
Feasibility of improving manufacturability based on protein engineering
2023-11-23
Abstract excerpt
While bioactivity and a favorable safety profile for biotherapeutics is of utmost importance, manufacturability is also worth of consideration to ease the manufacturing process. Many biotherapeutics are typically expressed in mammalian cells. Process-related impurities or biological impurities like viruses and host cell proteins (HCP) are present in the harvest which have mostly acid isoelectric points and need to...
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Identifiers and source
- Literature Corpus work
- e41bb3de-b422-5f2c-a8a6-34ab9951ce4a
- DOI
- 10.1101/2023.11.23.568267