Article

Microbial oral-gut translocation in advanced chronic liver disease is linked to exacerbation of intestinal barrier dysfunction and hepatic fibrosis

2025-09-23

Abstract excerpt

While microbiome perturbations are associated with advanced chronic liver disease (ACLD), microbial disease mechanisms are poorly understood. Using multi-omics analyses of paired saliva and faecal samples from an ACLD cohort, we identified next-to-identical oral and gut bacterial strains (including Veillonella and Streptococcus spp. ) which increased in absolute abundance in the gut of ACLD patients. These trans...

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Literature Corpus work: e2ced408-8cf2-5690-9b0a-2ffa0a708009
DOI: 10.1101/2025.09.23.677032

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