Article

Loss of O-specific antigen shapes Pseudomonas aeruginosa population microbiogeography in murine preclinical pulmonary infection model

2024-10-21

Abstract excerpt

Chronic Pseudomonas aeruginosa infections are the hallmark of late-stage lung disease in individuals with cystic fibrosis. During chronic infection P. aeruginosa becomes the dominant bacteria in the airway. Within-host adaptation of P. aeruginosa leads to vast phenotypic and genetic population heterogeneity. In vitro studies show mutations in lipopolysaccharide (LPS) O-specific antigen changes the aggregate fo...

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Literature Corpus work: e28d9d09-3a71-5105-8f3f-a35105ac5a62
DOI: 10.1101/2024.10.21.619428

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Loss of O-specific antigen shapes <i>Pseudomonas aeruginosa</i> population microbiogeography in murine preclinical pulmonary infection model

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