Article

Mechanistic insights and clinical implications of cross-reactive anti-prophage antibodies and bacterial heteroresistance on phage therapeutic failure

2025-04-23

Abstract excerpt

Phage therapy is an exciting strategy against antimicrobial-resistant bacterial infections, but critical knowledge gaps regarding its clinical application persist. Studying a patient with a life-threatening, chronic bacterial infection who failed phage therapy, we uncovered important biological concepts with direct translational impact. Using longitudinal clinical samples, we found that patients can harbour pre-ex...

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Literature Corpus work: e2679330-791b-5e3d-afbe-0beb10874a6b
DOI: 10.1101/2025.04.22.650118

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