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A novel mechanism of ceftolozane-tazobactam resistance in <i>Pseudomonas aeruginosa</i> mediated by L2 β-lactamase

2026-03-13

Abstract excerpt

The prevalance of non-susceptibility to ceftolozane-tazobactam (C/T) among Pseudomonas aeruginosa remains low but novel mechanisms of C/T resistance are of concern. Herein, we describe a novel Pseudomonas aeruginosa genotype associated with high-level C/T resistance (>256/4 µg/mL) in a single patient. Whole genome sequencing of the isolate was compared to that of a susceptible isolate cultured from the same pati...

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Literature Corpus work
e1ff6bac-a3a8-570c-93d1-649c56054016
DOI
10.64898/2026.03.10.710737
Open publication

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A novel mechanism of ceftolozane-tazobactam resistance in <i>Pseudomonas aeruginosa</i> mediated by L2 β-lactamaseDOI 10.64898/2026.03.10.710737
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