Article
Exploring Mechanisms of Inhibition of Amyloid Seeding of Transthyretin
2018-06-28
Abstract excerpt
Amyloid deposition of the hormone transporter transthyretin causes familial and sporadic amyloidoses. The current treatment for familial cases is gene-therapy by liver transplantation. However, this procedure is often insufficient to stop subsequent cardiac deposition. Our recent work has shown that preformed amyloid fibrils present in the heart by the time of surgery can template or seed further polymerization o...
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Identifiers and source
- Literature Corpus work
- e1b69d32-f15d-5b84-9997-cfdf0ff17888
- DOI
- 10.1101/354720