Amyloid seeding of transthyretin by ex vivo cardiac fibrils and its inhibition

Abstract excerpt

Significance Transthyretin (TTR) cardiac amyloidosis is characterized by the deposition of TTR amyloid fibrils in the heart. No therapy is currently available for wild-type cardiac amyloidosis. Hereditary cases are treated by liver transplantation, a crude form of gene therapy which replaces amyloidogenic mutant TTR by the more stable wild-type form, with the goal of halting further deposition and disease...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Amyloidosis: Diagnosis, Treatment, Outcomes
• Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
• Share to Trace Elements in Health