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Microbiota Transplant Therapy (MTT) Improves Gastrointestinal Symptoms in Children with Pitt-Hopkins Syndrome: A Randomized Clinical Trial

2026-07-15

Abstract excerpt

<title>Abstract</title> <p> Pitt-Hopkins syndrome (PTHS) is an ultrarare neurodevelopmental disorder caused by <italic>TCF4</italic> gene mutations and frequently accompanied by severe gastrointestinal (GI) dysfunction, suggesting disruption of the gut-brain axis. We conducted a randomized, double-blind, placebo-controlled trial with open-label extension to evaluate microbiota transplant therapy (MTT) in seven...

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Literature Corpus work
e0a734e9-3d4d-5de1-8431-d504753027a2
DOI
10.21203/rs.3.rs-9930475/v1
Open publication

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Microbiota Transplant Therapy (MTT) Improves Gastrointestinal Symptoms in Children with Pitt-Hopkins Syndrome: A Randomized Clinical TrialDOI 10.21203/rs.3.rs-9930475/v1
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