Article

Convergent evolution of somatic escape variants in <i>SERPINA1</i> in the liver in alpha-1 anti-trypsin deficiency

2024-09-02

Abstract excerpt

Somatic variants accumulate in non-malignant tissues with age 1,2 . Functional variants leading to clonal advantage of hepatocytes accumulate in the liver from patients with acquired chronic liver disease (CLD) 3–5 . Whether these somatic variants are common to CLD from differing aetiologies is unknown. We analysed somatic variants in the liver from patients with genetic CLD from alpha-1 anti-trypsin (A1AT) defi...

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Literature Corpus work: dfaa485e-0bee-5bc1-a584-5fcd8ff73913
DOI: 10.1101/2024.09.02.610686

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