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Epigenetic mechanisms regulate sex differences in cardiac reparative functions of bone marrow progenitor cells

29 Apr 2024

Abstract excerpt

Historically, a lower incidence of cardiovascular diseases (CVD) and related deaths in women as compared with men of the same age has been attributed to female sex hormones, particularly estrogen and its receptors. Autologous bone marrow stem cell (BMSC) clinical trials for cardiac cell therapy overwhelmingly included male patients. However, meta-analysis data from these trials suggest a better functional outcome...

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PMID: 38684697
DOI: 10.1038/s41536-024-00362-2

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