Clinical and Pharmacogenomic Predictors of Survival in Tamoxifen Treated Breast Cancer Female Patients: A Real-World Study

Abstract excerpt

<title>Abstract</title> <p>Aim To investigate the impact of tamoxifen treatment coverage, <italic>CYP2D6</italic> inhibitors, <italic>CYP2D6*4</italic> genotype, and non-genetic parameters on the outcomes of tamoxifen treated female breast cancer patients. Method We retrospectively included 3218 female patients who initiated tamoxifen following a diagnosis of breast cancer with long-term follow-up (median 7.5 y...

Topics

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• Antineoplastic Agents, Hormonal
• Clinical Decision-Making
• Confounding Factors, Epidemiologic
• Cytochrome P-450 CYP2D6 Inhibitors
• Disease Management
• Practice Guidelines as Topic
• Receptors, Estrogen
• Tamoxifen

Identifiers and source

Literature Corpus work

dea69a68-b514-5014-b988-33b0897f0273

DOI

10.21203/rs.3.rs-4750239/v1