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The antimycotic 5-fluorocytosine is a virulence inhibitor of uropathogenic <i>Escherichia coli</i> and eradicates biofilm-embedded bacteria synergizing with β-lactams

2024-11-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objectives</h4> Biofilm increases bacterial antibiotic tolerance, posing a challenge for treating biofilm-associated infections in clinical settings. 5-fluorocytosine (5-FC), an FDA-approved antifungal and antitumor drug, has been shown to inhibit virulence factor production and biofilm formation in Gram-negative bacteria. This work aims to determine whether 5-FC antivirulence and antibiofi...

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Literature Corpus work: dea3ad67-0caa-5527-8d3b-d61c87c1db75
DOI: 10.1101/2024.11.20.624304

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